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Keep track of Closely (two)pentobarbital will minimize the level or result of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Potent CYP3A4 inducers may possibly lower suvorexant efficacy; if improved suvorexant dose required, usually do not exceed twenty mg/working dayRight after halting a CYP3A4 inducer, as